COVID vaccine trials lack important study participants
ATLANTA — Gwinnett County Transit driver Mikesha Walker talked to co-workers recently about whether they would participate in a COVID-19 vaccine research trial.They’re ideal participants, many researchers say. They spend more time with the public, which puts them at greater exposure to the disease. Many workers are Black, a demographic that is not adequately represented in trials.However, Walker said the drivers are very reluctant to participate. Many feel underappreciated and underpaid for continuing to work during the pandemic. They’re also aware of health studies done decades ago, such as t...
The Atlanta Journal-Constitution
Cuba is about to start testing its own COVID-19 vaccine, authorities say
MIAMI — Cuba will start testing its own COVID-19 vaccine candidate next week, according to the official Cuban registry of clinical trials.The vaccine, Soberana 01, was produced by the state-run Finlay Institute of Vaccines and will be tested during a phase I and II trial involving 676 adults between 19 and 80 years old. The results will not be published until February 2021.A phase I clinical trial evaluates a drug’s side effects and toxicity. If the results are good, the process can continue to a phase II trial to determine if the medication works.It’s unclear if a late-stage, phase III trial,...
COVID-19 vaccine trial kicks off in Florida, with volunteers getting up to $1,000
FORT LAUDERDALE, Fla. — Another major clinical trial is underway in the global race for a COVID-19 vaccine — with researchers this time planning to pay participants hundreds of dollars in Palm Beach County.The experimental vaccine, called AZD1222, was developed by AstraZeneca in conjunction with the University of Oxford. The drug arrived Monday morning to the campus of the JFK Medical Center in Atlantis, and the first 10 patients for the study will start the process Tuesday morning. The vaccine is one of just five that are in the crucial stage of Phase 3 testing, according to Dr. Larry Bush, l...
A coronavirus vaccine is on the horizon, thanks to a key discovery by these researchers
AUSTIN, Texas — When the latest coronavirus emerged, Jason McLellan and his team were ready to take action.McLellan, an associate professor of molecular biosciences at the University of Texas, has been studying respiratory diseases for years. In 2017, McLellan’s postdoctoral researcher Nianshuang Wang identified genetic mutations necessary to stabilize a key component of diseases like MERS, also a coronavirus.So when Chinese researchers shared the genetic sequence of the new coronavirus on Jan. 10, UT researchers were able to quickly map the virus and inject it with previously-discovered mutat...
Hydroxychloroquine is the most disappointing, disavowed drug that researchers keep studying for COVID-19
Barely three months ago, the anti-malarial drug that President Donald Trump touted seemed like such a sure bet against COVID-19 that Susanna Naggie had a tough time setting up a national clinical trial comparing it to placebo. Colleagues said giving a fake pill would be unethical since the real thing might save lives.Now, hydroxychloroquine, or HCQ, has fallen into such disfavor that healthcare workers are leery of Naggie’s trial. Called HERO (a loose acronym for HEalth Care Worker pROphylaxis Against COVID-19) it is designed to see if the drug can protect them from infection.“Our original rec...
The Philadelphia Inquirer
Nation and world news briefs
Moderna delays Phase 3 trial for COVID-19 vaccineModerna’s heavily anticipated trial for a coronavirus vaccine, which was set to begin next week, has been delayed.“Moderna has previously disclosed that the Phase 3 trial of its COVID-19 vaccine candidate mRNA-1273 is expected to begin in July. The trial is still expected to begin in July and we expect to be the first to start a Phase 3 trial,” read a company statement sent to The New York Daily News Thursday. “We have worked closely with NIH/OWS to align on the final protocol in order to begin the trial on time.”The Phase 3 study, which include...
Tribune News Service
Moderna delays Phase 3 trial for COVID-19 vaccine
Moderna’s heavily anticipated trial for a coronavirus vaccine, which was set to begin next week, has been delayed.“Moderna has previously disclosed that the Phase 3 trial of its COVID-19 vaccine candidate mRNA-1273 is expected to begin in July. The trial is still expected to begin in July and we expect to be the first to start a Phase 3 trial,” read a company statement sent to The New York Daily News Thursday. “We have worked closely with NIH/OWS to align on the final protocol in order to begin the trial on time.”The Phase 3 study, which includes 30,000 patients, was initially supposed to begi...
New York Daily News
For some with COVID-19, symptoms can linger for weeks, even months
ATLANTA — When Nina Dalsania Makadia felt the first symptoms of COVID-19 in March, she braced herself for a couple of miserable weeks.The Kennesaw, Ga., mother of three young children expected the virus to be like a bad cold or the flu. Her headache, chills and fever would require rest and recuperation in bed, she thought. After that, she’d be better, and life would return to normal.But things haven’t returned to normal for the 38-year-old.Three months since falling ill, Makadia still can’t shake extreme exhaustion. Even going up and down the stairs in her home leaves her winded. Then there’s ...
The Atlanta Journal-Constitution